![]() Also, I used to download lots of data into tables to analyze (way better to use a DBMS for that) and excel kept crashing on Windows computers no less- had a memory leak problem. Finally got tired of the out dated paradigm (one honking table per sheet? come on what year is this, Ribbon bar - yecch). I used to use MS Suite stuff cause I had to for work. Speaking of protection, I recommend that you do NOT install any anti-virus software. I also use Little Snitch and a VPN for protection. This leaves a lot of room for the iStat icons. I have over two dozen icons which I am hiding. The number of Cycles is currently 35 and the Current Capacity is 8600 mAh which is slightly below the Design Capacity of 8694 mAh. My battery health is 100% from a battery with a manufacture date of. I set the battery level to 80% and I Calibrate every two weeks. I have been using it over a year, the last eleven months on my M2 MBP Max. Plus, it helps the developer to stay in business. I suggest you buy the Pro version to get all the features. ![]() I am often referring to it in my MenuBar.Īl Dente is a fabulous piece of software. And it has alerted me, over the years, to some funny goings on which I had to address. I have been using iStat since it's been around. Now, if you want to start a fresh approach and don't mind a new learning curve, you will be happy switching.Ĭlick to expand.I can wholeheartedly recommend Al Dente and iStat Menus. the big honking single table Excel approach, versus the multiple specialized tables in Numbers makes for some quirky conversions - but you can share data, it is just cumbersome. While Numbers can and read and write excel. If you share Excel files with others, best to stick with it. If you read XML files in Excel, stick with it (I really haven't found a good alternative in Numbers, but it is not a problem for me because I don't use them often). If you use some of the more nuanced stuff in Excel, stick with it. always remember that the VBA in the MS Suite is a hackers delight (A shame really, I use to build embedded applications using it, so here is to MS fixing the security holes LOL) That being said, there is stuff in Excel, that if you use it, then you should stick with Excel, but most people don't use it. But Numbers is a great product with a much better (in my opinion) UI, does everything I need it to do and has never crashed. I'll admit for those familiar with Excel it is a transition, and most people don't like change. I switched to Numbers when I would have had to buy an Excel license, and have been totally happy with it. These third-party apps can do so by modifying the Battery Charge Level Max (BCLM) parameter in the SMC. AlDente is a popular application that limits the maximum charge level on Mac. Also, I used to download lots of data into tables to analyze (way better to use a DBMS for that) and excel kept crashing on Windows computers no less- had a memory leak problem.) Method 1- Limit MacBook Charging Using AlDente. Click to expand.I used to use MS Suite stuff cause I had to for work.
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For some the 1911 points like their index pletely natural. It's a matter of personal preferences and ergonomics. Then again many swear by the ancient 1911 Colt. There are newer designs that you may appreciate more.like the Springfield XD or SW M&P that have adjustable ergonomics. Nothing against Glocks, but they are an older design. That's why there are so many police agancies that use Glocks. Many folks love the Glock, but it's chief virtue these days is it's low cost. You're like a person that just got their driver's license and is shopping for a car. Suggest you find a range or take some practical pistolcraft training where you can try a number of different pistols before spending the bucks on one that you may regret later. Different features that may or may not be important to you. There are many fine handguns that will work equally well for you. ![]() How do they feel in your hand? Do you prefer having the DA/SA hammer over the more-or-less SA Glock striker? You aren't likely to die if you miss the shot on the deer or get embarrassed at the range because your safety was on.īeyond this, it's a matter of personal preference. Manual safeties are fine for hunting/target guns. Even if your gun was only for hunting or only for plinking, this is what you should be doing. In the end, you should be training yourself to keep your finger off the trigger until you're ready to shoot, anyway. You may then just yank the trigger over and over instead of flipping the safety off. That's bad enough, but, like I said earlier, you're not thinking too well in such situations. If you don't practice your draw a lot, to the point that flipping off the safety is a natural part of your gun coming out of its holster, you may forget to turn it off when you're having to draw on an assailant. ![]() When the adrenaline is pumping, you're not thinking, you're reacting. On manual safeties: I feel that the on/off lever safety has no place on a defensive gun. Unless you're talking the PX4 Subcompact, I think the Glock 19 will be more concealable. Here’s the door to Fractured Shrines after clearing Black Bridge and taking the elevator up. You can take Fractured Shrines to the second Fatal Falls DLC level, Undying Shores. But before you can do that, you’ll need to unlock a door at the end of the area guarded by spear-holding statues. The door to Undying Shores is locked by default – you’ll need a costume to get inside. While you’re carving a path through Fractured Shrines, be on the lookout for a dead cultist. The cultist corpse is easy to miss if you don’t know what you’re looking for. Using your possession ability (clicking in the right stick on a gamepad), you can “leave your body” and take over the cultist, resulting in a change of clothes. ![]() " The apostates' hideout isn't far, but I don't know what kind of welcome they reserve for strangers in need of help these days.The first time you steal the cultist outfit, you’ll see a little cutscene." I was hoping her people could help me, but they don't recognize me anymore.".In one of the treasure rooms that is guarded by a Stone Warden a secret room can be found with a bloody plant and a letter. " Though they could have mentioned the wardens."." They didn't lie when they said the Queen's temples were full of treasures waiting to be taken.".In one of the treasure rooms that is guarded by a Stone Warden a journal can be found. Grappling Hook, Knockback Shield, Robin Hood Outfitįlamethrower Turret, Cloud Outfit (3+ BSC) Wave of Denial, Powerful Grenade, Aphrodite Outfitīow and Endless Quiver, Infantry Bow, Ice Bow, Skeleton Outfit Seismic Strike, A Thousand and One Nights Outfit Lightning Bolt, Vampirism, Mage Outfit (2+ BSC)īlood Sword, Double Crossb-o-matic, Bobby Outfit (1+ BSC) When applicable, the minimum difficulty level for blueprint acquisition is specified in brackets.Ĭluster Grenade, Heavy Turret, No Mercy, Demon Outfit (3+ BSC) For each enemy, any common, uncommon, rare or legendary blueprints they carry are indicated. In the table below, you will find which enemies are present in the Fractured Shrines depending on difficulty level. In the Fractured shrines, there are three unique enemies: Myopic Crows, Stone Warden and Cold Blooded Guardians. The blueprints for the Iron Staff and Rocky Outfit are dropped by Stone Wardens and the blueprint for the Snake Fangs and Lizard Outfit are dropped by Cold Blooded Guardians. The Cultist Outfit blueprint can be obtained from the cultist corpses littering the large structures.The blueprint itself instantly goes into your inventory and still needs to be delivered to the Collector. By opening the vault, the player can free Serenade, which will force itself into one of their skill slots, causing the previous item to be dropped on the ground. In the building there is a Stone Warden guarding a door which leads to a unique treasure room with a vault inside. This leads to a building that can only be accessed from one side, although alternatively one can enter from the very top where there are 3 breakable floors stacked on top of each other if the player has acquired the Ram Rune. After that there is a small gauntlet of traps. There is an island that can be reached by platforming over invisible platforms. ![]()
![]() The verdict! Don’t make it if you can’t stop yourself from eating too many because it’s amazing!!! One little cluster however is perfect for kids lunch or snack!Ī note about cooking with sugar. The key is to get 2 cups worth of nuts and seeds, to 4 TBL worth of sweeteners. I did this a second time with only almonds. Use any mixture of nuts and seeds you like. By morning, your clusters will be well glued together!.Take out of oven and leave on the counter for several hours, preferable overnight to harden. Bake at 350 for at least 20 minutes, or until just before nuts start to brown.Scoop into a pan lined with parchment paper! (otherwise, tough to remove) (8X8 or 8 inch round pan).In a large bowl, combined nuts and seeds.Mix brown rice syrup and honey in a small bowl.(I have a feeling this jar will last for many years.) There was one organic jar that was almost $8, but I chose the un-organic one for $4. The health food store kept it by the honey/agave/maple syrup products. I also had to find Rice Syrup! I don’t shop specialty health food stores normally, but I wanted to get some rice syrup, since we’ve never used it before. ![]() I purchased some cashew pieces, almonds, sunflower seeds, and peanuts for mine. Not saying you can’t make this another way, but I wanted to copy the package exactly! The ingredients on the bag were:Ĭashews, Almonds, Cane Sugar, Pumpkin Seed Kernels, Rice Syrup, Sea Salt and Honey. And, as with all new foods, I looked at the ingredients and say to myself: I can make that! ha ha.
In case you want to see these girls in motion just watch Raylene and Romi doing various nude activities together. Their routine today included a shaved pussy for both of them. Broadcast this video to your subscribers: Send broadcast. Tag this video: Separate by commas (tag 1, tag 2. Porn twin lesbians new with two very strong orgasms Romi and Raylene. RomiAndRaylene-1080P Upload to unlock direct downloads Upload a video now continue. Reality action with nude flexible teens Raylene and Romi Bravotube 05:00. Amateur lesbians Natalie, Arianna with fingers in the vagina and twins Romi, Raylene banana. Sexy nude twins can never be a bad thing right? One of the best ways to tell these two apart is that one of them has a hairy pussy.well atleast till this morning. Masturbation Morning 1 With Raylene And Romi With Raylene Romi Manysex 07:20. Girls Naked Bed Sun Nude Faptastic Faptastisch Bett Schlafen Sleeping Hot Pussy Of A Sleeping Beauty Blond Girl Naked On Bed Naked Girls Nude Hairy Twat. They also appear to sleep nude which I have no problem with. ![]() It's morning which means it's time to wake up and twin sisters Raylene and Romi are no exception to that rule. Twins Raylene and Romi doing their morning routine ![]() ![]() ![]() These data argue that anti-tumor immune responses during or post-treatment are non-existent, ineffective or overcome by immune evasive mechanisms. Definitively, tumor repopulation during cytotoxic therapy regimens and the development of radio or chemoresistance remain a major cause of treatment failure 19, 20, 26. Similarly, extensive evidence supports the notion that dead cells can promote immunological tolerance or drive inflammatory responses that fuel tumor progression 22, 23, 24, 25. Various mechanisms have been proposed to explain the latter 19, 20, among which is the Révész effect, a long-appreciated phenomenon by which lethally-irradiated cancer cells stimulate the growth of live cells 21. In sharp contrast with these findings supporting immune-mediated benefit of cytotoxic agents, preclinical and clinical data indicate that these treatments can paradoxically have detrimental protumorigenic effects. In non-small cell lung cancer (NSCLC) 12, 13, urothelial cancer 14 and triple negative breast cancer (TNBC) 15, 16, 17, 18, among other cancer types, combinations of CTX and ICB are already approved and used as first-line treatments 11. Accordingly, various studies exposed the benefit of combining immune checkpoint inhibitors and cytotoxic therapy 8, 9, 10 and numerous clinical trials are currently evaluating these combinations across cancer types 11. Moreover, some cytotoxic agents, often referred to as immunogenic cell death (ICD) inducers, have been shown to be more efficient than others at promoting immune-mediated control 3. Certain modalities of cell death can drive tumor-specific T cell responses and growth control through exposure of cancer cell-associated target antigens and stimulation of antigen presenting cells 2, 5, 6, 7. These observations are consistent with the view that release of damage-associated molecular patterns (DAMPs) 4 and production of inflammatory mediators by dying cancer cells 5, 6 can boost cancer-restraining immune responses. Hallmark cellular and molecular mediators of anti-cancer immune responses are indispensable for, and correlate with, the efficacy of cytotoxic therapy in animal models and human cancers, respectively 3. In addition to their direct killing of cancer cells, numerous studies have also highlighted a major role for the immune system in mediating the efficacy of these therapies 2, 3. Tumor shrinkage following CTX and radiotherapy has been largely attributed to the damaging effects of these cytotoxic agents on rapidly proliferating cancer cells. Despite these advances, cytotoxic therapies, such as chemotherapy (CTX) or radiotherapy, remain the standard of care for most unresectable or advanced malignancies, including in adjuvant and neoadjuvant settings. Immune checkpoint blockade (ICB) therapies targeting the cytotoxic T lymphocyte-associated antigen-4 and programmed cell death (PD)−1 pathways have transformed the landscape of cancer treatment 1. Our findings suggest COX-2/PGE 2 upregulation by dying cancer cells acts as a major barrier to cytotoxic therapy-driven tumor immunity and uncover a strategy to improve the outcomes of immunotherapy and chemotherapy combinations. ![]() Crucially, in a poorly immunogenic breast cancer model, only the triple therapy unleashes tumor growth control and significantly reduces relapse and spontaneous metastatic spread in an adjuvant setting. Pharmacological COX-2 inhibition boosts the efficacy of the combination of chemotherapy and PD-1 blockade. Genetic manipulation of COX-2 expression or its gene promoter region uncover how augmented COX-2/PGE 2 activity post-treatment profoundly alters the inflammatory properties of chemotherapy-treated cancer cells in vivo. Screening a compound library of 1280 approved drugs, we find that all classes of chemotherapy drugs enhance COX-2 transcription whilst arresting cancer cell proliferation. Here, we show that cytotoxic therapy acutely upregulates cyclooxygenase (COX)-2 expression and prostaglandin E 2 (PGE 2) production in cancer cells with pre-existing COX-2 activity. The underlying mechanisms dictating these opposing outcomes are poorly defined. Cytotoxic therapies, besides directly inducing cancer cell death, can stimulate immune-dependent tumor growth control or paradoxically accelerate tumor progression. ![]() These include social justice (structuring the basic institutions of society), distributive justice (distributing benefits and burdens), corrective justice (repairing past injustices), retributive justice (determining how to appropriately punish wrongdoers), and restorative or transformational justice (restoring relationships or transforming social structures as an alternative to criminal punishment). There are different types of justice that address what people are due in various contexts. Equal treatment implies that people should be treated as equals according to some defensible standard such as merit or need, but not necessarily that everyone should be treated in the exact same way in every respect. Justice is the idea that each person should be given their due, and what people are due is often interpreted as fair or equal treatment. ![]() ( For further elaboration on the rights lens, please see our essay, “Rights.”) The Justice Lens Rights are also often understood as implying duties-in particular, the duty to respect others' rights and dignity. The list of moral rights-including the rights to make one's own choices about what kind of life to lead, to be told the truth, not to be injured, to a degree of privacy, and so on-is widely debated some argue that non-humans have rights, too. On the basis of such dignity, they have a right to be treated as ends in themselves and not merely as means to other ends. This approach starts from the belief that humans have a dignity based on their human nature per se or on their ability to choose freely what they do with their lives. Some suggest that the ethical action is the one that best protects and respects the moral rights of those affected. They have suggested a variety of different lenses that help us perceive ethical dimensions. If our ethical decision-making is not solely based on feelings, religion, law, accepted social practice, or science, then on what basis can we decide between right and wrong, good and bad? Many philosophers, ethicists, and theologians have helped us answer this critical question. Some things may be scientifically or technologically possible and yet unethical to develop and deploy. But science alone does not tell us what we ought to do. Social and natural science can provide important data to help us make better and more informed ethical choices. While assessing norms, it is important to recognize how one’s ethical views can be limited by one’s own cultural perspective or background, alongside being culturally sensitive to others. Cultures can include both ethical and unethical customs, expectations, and behaviors. Ethics is not the same as following culturally accepted norms.Law may also have a difficult time designing or enforcing standards in some important areas and may be slow to address new problems. Law can become ethically corrupt-a function of power alone and designed to serve the interests of narrow groups. A good system of law does incorporate many ethical standards, but law can deviate from what is ethical. Ethics is not the same thing as following the law.Religious traditions can, however, develop and advocate for high ethical standards, such as the Golden Rule. Many people are not religious but act ethically, and some religious people act unethically. And, often, our feelings will tell us that it is uncomfortable to do the right thing if it is difficult. However, while some people have highly developed habits that make them feel bad when they do something wrong, others feel good even though they are doing something wrong. ![]() Feelings do provide important information for our ethical choices. It is helpful to identify what ethics is NOT: It requires knowledge, skills, and habits. Ethics is also concerned with our character. What is Ethics?Įthics refers to standards and practices that tell us how human beings ought to act in the many situations in which they find themselves-as friends, parents, children, citizens, businesspeople, professionals, and so on. Ethics really has to do with all these levels-acting ethically as individuals, creating ethical organizations and governments, and making our society as a whole more ethical in the way it treats everyone. We all have an image of our better selves-of how we are when we act ethically or are “at our best.” We probably also have an image of what an ethical community, an ethical business, an ethical government, or an ethical society should be. Read more about what the framework can (and cannot) do. This document is designed as an introduction to thinking ethically. ![]() We recommend using a blank USB or blank DVD,īecause any content on it will be deleted. A blank USB flash drive with at least 8GB of space or blank DVD (andĭVD burner) if you want to create media.Sufficient data storage available on a computer, USB or external drive for the download. ![]() An internet connection (internet service provider fees may apply).Using the tool to create installation media (USB flash drive, DVD, or ISO file) to install Windows 10 on a different PC (click to show more or less information)įollow these steps to create installation media (USB flash drive or DVD) you can use to installĪ new copy of Windows 10, perform a clean installation, or reinstall Windows 10.īefore you download the tool make sure you have:.It might take some time to install Windows 10, and your PC will restart a few times. ![]()
![]() There are currently many websites that try to gather user data using various techniques. AdGuard’s MOD APK version MOD functionĭownload the Android MOD for AdGuard Premium APK andamp. AdGuard gives users the power to manage their browsing experience and take advantage of a more enjoyable, secure, and private online experience with its customizable filtering rules, parental control options, cross-platform availability. In conclusion, AdGuard is an effective ad-blocking and privacy-protection app with many features to improve browsing, block intrusive ads, safeguard user privacy, and make the internet safer. In order to help users with any questions or problems they may have, the app also offers responsive customer support. ![]() ![]() Users are protected against the most recent ad formats and tracking techniques thanks to this. To keep up with the constantly changing landscape of online advertisements and tracking methods, AdGuard regularly updates its filter lists and algorithms. This cross-platform accessibility makes sure that users can experience consistent ad blocking and privacy protection across their devices. Cross-Platform AcceptanceĪdGuard is accessible on a variety of platforms, including popular web browser browser extensions for Android, iOS, Windows, and macOS. It can restrict tracking and ads across different apps, enhancing user privacy and the overall app experience. management of appsĪdGuard extends its functionality to apps installed on the device in addition to blocking ads and protecting privacy in web browsers. AdGuard can identify and filter out unwanted content by decrypting and analyzing encrypted traffic, giving all websites - including those with secure HTTPS connections- a consistent ad blocking and privacy protection experience. Filtering HTTPSĪdGuard can block ads and trackers even on encrypted websites because it supports HTTPS filtering. Users can adjust the ad blocking and privacy protection settings to suit their preferences and browsing habits thanks to this flexibility. Users can design their own unique filters to define exceptions for particular websites or block particular ad types. Users can adjust AdGuard’s filtering policies and preferences to meet their particular requirements. To shield their kids from explicit or harmful content, parents can also restrict access to particular websites or content categories. Users can adjust filtering settings based on various age groups, giving young users a secure and age-appropriate browsing experience. Users of AdGuard can filter and block inappropriate content for kids using a variety of parental control tools. It scans websites in real-time and blocks access to malicious content, preventing users from inadvertently visiting harmful websites or falling victim to online scams. The app includes a built-in Browling safely feature that warns users about potentially dangerous websites and protects against phishing attacks and malware-infected sites. This safeguards user privacy and stops the display of personalized advertisements. Users are effectively protected from unwanted tracking and profiling by blocking a variety of tracking technologies, such as cookies, web beacons, and social media trackers. Privacy Defenseīy preventing websites from gathering and storing user data, AdGuard provides comprehensive privacy protection. AdGuard reduces data usage, increases overall browsing speed, and offers a clutter-free browsing experience by blocking ads. In order to identify and get rid of intrusive ads, such as banner advertisements, pop-ups, video ad, and others, it combines pre-existing filter lists with its own filtering algorithms. The AdGuard app’s key features are described in detail below: Blocking adsīlocking advertisements across various websites and apps is one of AdGuard’s main responsibilities. AdGuard aids users in blocking intrusive ads, preventing tracking, and safeguarding against malicious content with its cutting-edge features and powerful filtering capabilities. Download the Android MOD for AdGuard Premium APK andamp.ĪdGuard is a comprehensive and potent privacy protection app that blocks ads and enhances the browsing experience while giving users an online environment that is safer and more secure. ![]() These tags are also used for some models from other brands such as Acer, BenQ, Epson, Hitachi, HP, Maginon, Minolta, Pentax, Ricoh, Samsung, Sanyo, SeaLife, Sony, Supra and Vivitar. These tags are used in Olympus cameras, and are the same as Konica/Minolta tags. These tags are used in DPX (Digital Picture Exchange) images. These tags used in PSD and PSB files, as well as inside embedded Photoshop information in many other file types (JPEG, TIFF, PDF, PNG to name a few). These tags are used in the ACR-NEMA specification. These tags are used in CRW-format Canon RAW files. These tags are used in many different types of audio, video and image files (most notably, MOV/MP4 videos and HEIC/CR3 images). These tags are used in Canon formats such as CR2, CR3 and CRM. These tags are used by Canon Digital Photo Professional which writes VRD (Recipe Data) information as a trailer record to JPEG, TIFF, CRW and CR2 images, or as stand-alone VRD or DR4 files. These tags are used in BPG files (Better Portable Graphics). These tags are used in ARW images by the Sony Image Data Converter utility. Some of these tags have been inherited from the Minolta MakerNotes. ICC profile information is used in many different file types including JPEG, TIFF, PDF, PostScript, Photoshop, PNG, MIFF, PICT, QuickTime, XCF and some RAW formats. Information in this format can be embedded in many different image file types including JPG, JP2, TIFF, GIF, EPS, PDF, PSD, IND, INX, PNG, DJVU, SVG, PGF, MIFF, XCF, CRW, DNG and a variety of proprietary TIFF-based RAW images, as well as MOV, AVI, ASF, WMV, FLV, SWF and MP4 videos, and WMA and audio formats supporting ID3v2 information. XMP stands for "Extensible Metadata Platform", an XML/RDF-based metadata format which is being pushed by Adobe. IPTC information may be found in JPG, TIFF, PNG, MIFF, PS, PDF, PSD, XCF and DNG images. The IPTC tags are part of the International Press Telecommunications Council (IPTC) and the Newspaper Association of America (NAA) Information Interchange Model (IIM). This type of information is formatted according to the TIFF specification, and may be found in JPG, TIFF, PNG, JP2, PGF, MIFF, HDP, PSP and XCF images, as well as many TIFF-based RAW images, and even some AVI and MOV videos. File TypeĮXIF stands for "Exchangeable Image File Format". Notation: R: Read / W: Write / C : Create. |
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